Transcriptomics

Dataset Information

9

RNA-Seq of E. caballus cartilage to investigate transcriptomic signatures of ageing


ABSTRACT: Equine cartilage from young and old donors was used for RNA-Seq analysis. The aim of the study was to identify differentially expressed cartilage transcripts in ageing in order to to characterize molecular mechanisms associated with age-related changes in

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Equus caballus  

SUBMITTER: Mandy J Peffers  

PROVIDER: E-MTAB-1386 | ArrayExpress | 2014-01-11

SECONDARY ACCESSION(S): ERP002039

REPOSITORIES: ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-MTAB-1386.idf.txt Idf
E-MTAB-1386.sdrf.txt Txt
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Publications

Transcriptomic profiling of cartilage ageing.

Peffers Mandy Jayne MJ   Liu Xuan X   Clegg Peter David PD  

Genomics data 20140319


The musculoskeletal system is severely affected by the ageing process, with many tissues undergoing changes that lead to loss of function and frailty. Articular cartilage is susceptible to age related diseases, such as osteoarthritis. Applying RNA-Seq to young and old equine cartilage, we identified an over-representation of genes with reduced expression relating to extracellular matrix, degradative proteases, matrix synthetic enzymes, cytokines and growth factors in cartilage from older donors.  ...[more]

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