Transcriptomics

Dataset Information

238

Transcription profiling by array of lymphoblasts derived from Diamond-Blackfan anemia patients carrying RPS19 or RPL11 mutations and those derived from healthy individuals


ABSTRACT: comparative expression analysis of polysomal mRNA from Diamond-Blackfan anemia patients and healthy individuals

ORGANISM(S): Homo sapiens  

SUBMITTER: Marian Groot Koerkamp  

PROVIDER: E-MTAB-1427 | ArrayExpress | 2014-07-01

REPOSITORIES: ArrayExpress

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Publications

Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes.

Pereboom Tamara C TC   Bondt Albert A   Pallaki Paschalina P   Klasson Tim D TD   Goos Yvonne J YJ   Essers Paul B PB   Groot Koerkamp Marian J A MJ   Gazda Hanna T HT   Holstege Frank C P FC   Costa Lydie Da LD   MacInnes Alyson W AW  

Experimental hematology 20140123 5


Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome linked to mutations in ribosomal protein (RP) genes that result in the impaired proliferation of hematopoietic progenitor cells. The etiology of DBA is not completely understood; however, the ribosomal nature of the genes involved has led to speculation that these mutations may alter the landscape of messenger RNA (mRNA) translation. Here, we performed comparative microarray analysis of polysomal mRNA transcripts isolated from lymph  ...[more]

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