Dataset Information


Methylation profiling by array of human huh7.5.1 cells after HCV-JFH1 viral infection to reveal how methylation status is affected by hepatitis viral infection

ABSTRACT: Genome wide DNA methylation analysis usig two individual huh7.5.1 after HCV-JFH1 infection

ORGANISM(S): Homo sapiens  

SUBMITTER: okamoto yasuyuki  

PROVIDER: E-MTAB-1473 | ArrayExpress | 2014-01-03


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BACKGROUND & AIMS: Cells of tumors associated with chronic inflammation frequently have altered patterns of DNA methylation, including hepatocellular carcinomas. Chronic hepatitis has also been associated with aberrant DNA methylation, but little is known about their relationship. METHODS: Pyrosequencing was used to determine the methylation status of cultured Huh7.5.1 hepatoma cells after hepatitis C virus (HCV) infection. We also studied mice with severe combined immunodeficiency carrying the  ...[more]

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