Transcriptomics

Dataset Information

19

Transcription profiling by array of human CD40L+ T cells to assess the nature of CD8+CD40L+ memory T cells


ABSTRACT: To assess the nature of CD8+CD40L+ memory Tcells, we compared the gene expression to CD8+CD40L- and CD4+ counterparts, and found similarities in expression of genes encoding cytokines. PBMCs were isolated from five healthy donors. The cells were stimulated with PMA/Ionomycin for 6 h, and subsequently sorted into the CD4+CD45RA-CD40L+, CD8+CD45RA-CD40L-, CD8+CD45RA-CD40L+ populations by FACS-sort.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ulrik Ulrik Stervbo  

PROVIDER: E-MTAB-1497 | ArrayExpress | 2019-01-30

REPOSITORIES: ArrayExpress

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Publications


CD8(+) T cells play an essential role in immunity against intracellular pathogens, with cytotoxicity being considered their major effector mechanism. However, we here demonstrate that a major part of central and effector memory CD8(+) T cells expresses CD40L, one key molecule for CD4(+) T-cell-mediated help. CD40L(+) CD8(+) T cells are detectable among human antigen-specific immune responses, including pathogens such as influenza and yellow fever virus. CD40L(+) CD8(+) T cells display potent hel  ...[more]

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