Transcriptomics

Dataset Information

238

Transcription profiling by array of serum mRNA in patients with head and neck squamous cell carcinoma


ABSTRACT: With the increasing demand for non-invasive approaches in monitoring of head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of HNSCC patients in comparison to healthy individuals. We compared gene expression patterns of thirty-five samples. Twenty-four participants including 16 HNSCC patients (from 11 patients we obtained blood samples 1 year after treatment) and 8 control subjects were recruited. The Illumina Human-6 v 3 Expression BeadChip were used to profile and identify the differences in serum mRNA transcriptomes between cancer patients and healthy controls as well as the differences in serum mRNA transcriptomes between patient???s serum from the same donor obtained before surgery and then one year after treatment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Karel Jr Smetana   Hynek Strnad   Jana Sachova   Jan Plzak   Zdenek Cada  Cestmir Vlcek  Michal Kolar  Miluse Hroudova  Martin Chovanec  Martin Steffl  Jaroslav Valach  Marketa Capkova 

PROVIDER: E-MTAB-1516 | ArrayExpress | 2014-02-20

REPOSITORIES: ArrayExpress

altmetric image

Publications

Microarray analysis of serum mRNA in patients with head and neck squamous cell carcinoma at whole-genome scale.

Čapková Markéta M   Šáchová Jana J   Strnad Hynek H   Kolář Michal M   Kolář Michal M   Hroudová Miluše M   Chovanec Martin M   Čada Zdeněk Z   Šteffl Martin M   Valach Jaroslav J   Kastner Jan J   Vlček Čestmír Č   Smetana Karel K   Smetana Karel K   Plzák Jan J  

BioMed research international 20140423


With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compared gene expression patterns of 36 samples. Twenty-four participants including 16 HNSCC patients (from 12 patients we obtained blood samples 1 year posttreatment) and 8 control subje  ...[more]

Similar Datasets

2014-11-22 | E-GEOD-63545 | ArrayExpress
2008-11-27 | E-GEOD-11264 | ArrayExpress
2016-02-23 | E-GEOD-78214 | ArrayExpress
2018-09-19 | PXD009241 | Pride
2014-12-19 | E-GEOD-40020 | ArrayExpress
2014-09-01 | E-GEOD-27543 | ArrayExpress
2016-10-25 | E-MTAB-4854 | ArrayExpress
2015-03-04 | E-GEOD-40774 | ArrayExpress
2015-06-24 | E-GEOD-65858 | ArrayExpress
2011-05-31 | E-GEOD-23036 | ArrayExpress