Transcriptomics

Dataset Information

239

Methylation profiling by array of human U937 cells treated with demethylating drugs 5-azacytidine and CP-4200 for 72 hours


ABSTRACT: array-based analysis of genome-wide DNA methylation changes induced by the demethylating drugs 5-azacytidine and CP-4200 on U937 cells for 72 hours

ORGANISM(S): Homo sapiens  

SUBMITTER: Maria Rius  

PROVIDER: E-MTAB-1529 | ArrayExpress | 2013-07-24

REPOSITORIES: ArrayExpress

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Publications

The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cells.

Hummel-Eisenbeiss Johanna J   Hascher Antje A   Hals Petter-Arnt PA   Sandvold Marit Liland ML   Müller-Tidow Carsten C   Lyko Frank F   Rius Maria M  

Molecular pharmacology 20130628 3


The nucleoside analog 5-azacytidine is an archetypical drug for epigenetic cancer therapy, and its clinical effectiveness has been demonstrated in the treatment of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML). However, therapy resistance in patients with MDS/AML remains a challenging issue. Membrane proteins that are involved in drug uptake are potential mediators of drug resistance. The responsible proteins for the transport of 5-azacytidine into MDS/AML cells are unknow  ...[more]

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