Dataset Information


Transcription profiling by array of mouse colon mucosal tissues isolated every 4 hours within a 24-hour period to study genes involved in circadian regulation

ABSTRACT: In mammals circadian clocks are present not only in the hypothalamus but also in all peripheral organs where they rhytmically control tissue specific biological processes. Here, the transcriptome of the mouse colon mucosa was analysed around the clock to identify genes whose gne expression is under circadian regulation.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Franck Delaunay  

PROVIDER: E-MTAB-1576 | ArrayExpress | 2014-03-18


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Functional genomics identify Birc5/survivin as a candidate gene involved in the chronotoxicity of cyclin-dependent kinase inhibitors.

Siffroi-Fernandez Sandrine S   Dulong Sandrine S   Li Xiao-Mei XM   Filipski Elisabeth E   Gréchez-Cassiau Aline A   Peteri-Brünback Brigitta B   Meijer Laurent L   Lévi Francis F   Teboul Michèle M   Delaunay Franck F  

Cell cycle (Georgetown, Tex.) 20140121 6

The circadian timing system orchestrates most of mammalian physiology and behavior in synchrony with the external light/dark cycle. This regulation is achieved through endogenous clocks present in virtually all body cells, where they control key cellular processes, including metabolism, transport, and the cell cycle. Consistently, it has been observed in preclinical cancer models that both the efficacy and toxicity of most chemotherapeutic drugs depend on their time of administration. To further  ...[more]

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