Genomics

Dataset Information

297

ChIP-seq of first branchial arch cells from E11.5 mouse embryos with anti-pan-Meis antibodies


ABSTRACT: Chromatin immunoprecipitation using pan-Meis antibodies in first branchial arch cells from E11.5 mouse embryos detected by SOLiD sequencing

INSTRUMENT(S): AB SOLiD 4 System

ORGANISM(S): Mus musculus  

SUBMITTER: Ian J Donaldson  

PROVIDER: E-MTAB-1631 | ArrayExpress | 2015-02-02

SECONDARY ACCESSION(S): ERP002531

REPOSITORIES: ArrayExpress, ENA

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Publications

Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.

Amin Shilu S   Donaldson Ian J IJ   Zannino Denise A DA   Hensman James J   Rattray Magnus M   Losa Marta M   Spitz François F   Ladam Franck F   Sagerström Charles C   Bobola Nicoletta N  

Developmental cell 20150129 3


Hox transcription factors (TFs) are essential for vertebrate development, but how these evolutionary conserved proteins function in vivo remains unclear. Because Hox proteins have notoriously low binding specificity, they are believed to bind with cofactors, mainly homeodomain TFs Pbx and Meis, to select their specific targets. We mapped binding of Meis, Pbx, and Hoxa2 in the branchial arches, a series of segments in the developing vertebrate head. Meis occupancy is largely similar in Hox-positi  ...[more]

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