Dataset Information


Transcription profiling of yeast to determine polysome-associated mRNAs after 90 minutes of mRNA mistranslation induction

ABSTRACT: Polysome-associated transcriptome analysis in cells after 90 minutes of mistranslation induction comparing with a pool of mRNAs existent in cells without induction at several time points (Reference)

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Joao Paredes   Manuel Santos 

PROVIDER: E-MTAB-166 | ArrayExpress | 2010-02-01


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Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast.

Paredes João A JA   Carreto Laura L   Simões João J   Bezerra Ana R AR   Gomes Ana C AC   Santamaria Rodrigo R   Kapushesky Misha M   Moura Gabriela R GR   Santos Manuel A S MA  

BMC Biology 20120620

BACKGROUND: Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneration and premature death in mice and mitochondrial disorders in humans. Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and b  ...[more]

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