Transcriptomics

Dataset Information

356

Transcription profiling by array of TS23 humerus tissue from muscle-less mutant (splotch-delayed) mice and control littermates to identify differentially expressed genes between muscle-less and control embryonic (TS23) humerus tissue, in order to determine mechanosensitive genes that impact skeletal development


ABSTRACT: Microarray profiling analysis was performed on TS23 humerus tissue from muscle-less mutant (splotch-delayed) mice and compared to control littermates. The purpose of this profiling analysis was to identify differentially expressed genes between muscle-less and control embryonic (TS23) humerus tissue, in order to determine mechanosensitive genes that impact skeletal development.

REANALYSED by: E-MTAB-1744

ORGANISM(S): Mus musculus  

SUBMITTER: Rebecca A Rolfe  

PROVIDER: E-MTAB-1744 | ArrayExpress | 2013-09-01

REPOSITORIES: ArrayExpress

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Publications

Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways.

Rolfe Rebecca A RA   Nowlan Niamh C NC   Kenny Elaine M EM   Cormican Paul P   Morris Derek W DW   Prendergast Patrick J PJ   Kelly Daniel D   Murphy Paula P  

BMC genomics 20140120


Mechanical stimulation is necessary for regulating correct formation of the skeleton. Here we test the hypothesis that mechanical stimulation of the embryonic skeletal system impacts expression levels of genes implicated in developmentally important signalling pathways in a genome wide approach. We use a mutant mouse model with altered mechanical stimulation due to the absence of limb skeletal muscle (Splotch-delayed) where muscle-less embryos show specific defects in skeletal elements including  ...[more]

Publication: 1/2

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