Dataset Information


Transcription profiling by array of xenografted tumors derived from human ovarian cell line model A2780 and its cisplatin resistant variant A2780cis

ABSTRACT: Molecular mechanisms underlying the development of resistance to platinum treatment in patients with ovarian cancer remain poorly understood. This is mainly due to the lack of appropriate in vivo models allowing identification of factors that are regulated during initial treatment and of acquired resistance-related genes. In this study, we used whole genome microarrays and linear model analysis to identify potential resistance-related genes by comparing the expression profiles of the parental human ovarian cancer model A2780 and its cisplatin-resistant variant A2780cis, before and after carboplatin treatment in vivo.

ORGANISM(S): Homo sapiens  

SUBMITTER: Julia C. Meier  

PROVIDER: E-MTAB-1858 | ArrayExpress | 2013-10-01


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