Transcriptomics

Dataset Information

415

MiR-100-mediated gene expression changes


ABSTRACT: The miR-99 family is one of the evolutionarily most ancient microRNA families, and it plays a critical role in development. There are 3 members of the miR-99 family in humans (miR-99a, miR-99b, miR-100). Recent studies suggested that miR-99 family also regulates various physiological processes in adult tissues, such as wound healing, and a number of diseases processes, including cancer. Here, we aim to identify gene expression changes mediated by miR-99 family in epithelial cells. HaCaT cells and 1386Ln cells were transfected with miR-100 mimic or with negative control mimic (Dharmacon), the total RNA was isolated using miRNeasy Mini kit (Qiagen), and labeled and hydridized to the Affymetrix GeneChip Human Gene 1.0 ST arrays according standard protocol.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Xiaofeng Zhou  

PROVIDER: E-MTAB-1876 | ArrayExpress | 2013-11-19

REPOSITORIES: ArrayExpress

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Publications

MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells.

Chen Dan D   Chen Zujian Z   Jin Yi Y   Dragas Dragan D   Zhang Leitao L   Adjei Barima S BS   Wang Anxun A   Dai Yang Y   Zhou Xiaofeng X  

PloS one 20131203 12


The miR-99 family is one of the evolutionarily most ancient microRNA families, and it plays a critical role in developmental timing and the maintenance of tissue identity. Recent studies, including reports from our group, suggested that the miR-99 family regulates various physiological processes in adult tissues, such as dermal wound healing, and a number of disease processes, including cancer. By combining 5 independent genome-wide expression profiling experiments, we identified a panel of 266  ...[more]

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