Transcriptomics

Dataset Information

14

Transcription profiling by array of CD4(+) T-cells from non-obese diabetes (NOD) strain with or without Idd6.3 candidate gene Arntl2 overexpression and from two NOD.C3H Idd6.3 congenic strains


ABSTRACT: The locus Idd6.3 influences type 1 diabetes in the nonobese diabetes (NOD) mouse via control of the activity of splenocytes and T cells. C3H alleles at Idd6.3 are more protective in diabetes transfer assays than NOD alleles. In this experiment we compare splenic CD4(+) T cells derived from two NOD.C3H Idd6.3 congenic strains (6.VIIIa, NOD alleles; 6.VIIIc, C3H alleles) and NOD CD4(+) T cells overexpressing the Idd6.3 candidate gene Arntl2 or not. The aim of the study is to evaluate genes and genetic networks under control of Idd6.3 and/or Arntl2.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Ute Christine Rogner  

PROVIDER: E-MTAB-1957 | ArrayExpress | 2014-09-06

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MTAB-1957.idf.txt Idf
E-MTAB-1957.processed.1.zip Processed
E-MTAB-1957.raw.1.zip Raw
E-MTAB-1957.sdrf.txt Txt
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