Transcriptomics

Dataset Information

48

DNA copy number profiling of canine osteosarcoma


ABSTRACT: Identification of DNA copy number imbalances in 22 spontaneous canine osteosarcoma cases using array comparative genomic hybridization (aCGH) analysis

ORGANISM(S): Canis lupus familiaris  

SUBMITTER: Rachael Thomas  

PROVIDER: E-MTAB-1986 | ArrayExpress | 2013-11-01

REPOSITORIES: ArrayExpress

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Publications


Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible.Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited risk loci explaining 55% to 85% of phenotype variance in each breed. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine  ...[more]

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