Genomics

Dataset Information

297

ChIP-seq of pancreatic progenitor cells derived in vitro from human embryonic stem cells in order to study the epigenomic mechanisms involved in pancreas development


ABSTRACT: Active regulatory regions in the human embryonic pancreatic progenitors were profiled by integration of transcription factor and histone modification ChIP-seq datasets. These were obtained from pancreatic progenitor cells derived in vitro from human embryonic stem cells. The purpose of this work was to study the epigenomic mechanisms involved in pancreas development.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: Santiago A Rodriguez-Segui   Jorge Ferrer  

PROVIDER: E-MTAB-1990 | ArrayExpress | 2013-11-15

SECONDARY ACCESSION(S): ERP004206

REPOSITORIES: ArrayExpress, ENA

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Publications


The contribution of cis-regulatory mutations to human disease remains poorly understood. Whole-genome sequencing can identify all noncoding variants, yet the discrimination of causal regulatory mutations represents a formidable challenge. We used epigenomic annotation in human embryonic stem cell (hESC)-derived pancreatic progenitor cells to guide the interpretation of whole-genome sequences from individuals with isolated pancreatic agenesis. This analysis uncovered six different recessive mutat  ...[more]

Publication: 1/2

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