Transcriptomics,Multiomics

Dataset Information

3

CLCGP


ABSTRACT: Fresh frozen samples of lung tumors were analyzed. RNA was extracted using Qiagen extraction Mini-Kit. cRNA was prepared using standard Illumina protocols. BeadStudio 3.1.1.0 was used to extract data.

ORGANISM(S): Homo sapiens  

DISEASE(S): Lung Cancer

SUBMITTER: Martin Peifer  

PROVIDER: E-MTAB-1999 | ArrayExpress | 2013-10-17

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MTAB-1999.idf.txt Idf
E-MTAB-1999.raw.1.zip Raw
E-MTAB-1999.sdrf.txt Txt
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Publications

A genomics-based classification of human lung tumors.

Science translational medicine 20131001 209


We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration potentially amenable to specific therapeutic intervention, including several personalized treatment approaches that are already in clinical evaluation. Marked differences in the pattern of genomic alterations existed between and within histological subtyp  ...[more]

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