Transcriptomics

Dataset Information

121

Novel PAX5 fusion genes in childhood B-Cell Precursors Acute Lymphoblastic Leukemia


ABSTRACT: PAX5, a transcription factor essential for B-cell development, has been found as a frequent target of abnormalities in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) cases, showing point mutations, deletions, as well as translocations with several partner genes. We identified four novel PAX5 fusion partner genes by performing a screening on BCP-ALL cases with 9p rearrangements. Copy Number Variation analysis of translocated samples showed that few significant cooperative genetic lesions are present in addition to the translocation event, suggesting that it might have a primary role in leukemogenesis.

INSTRUMENT(S): Affymetrix Fluidics Station

ORGANISM(S): Homo sapiens  

SUBMITTER: Grazia Fazio  

PROVIDER: E-MTAB-2416 | ArrayExpress | 2015-03-02

REPOSITORIES: ArrayExpress

Similar Datasets

2015-02-09 | E-GEOD-64122 | ArrayExpress
2015-02-09 | E-GEOD-64121 | ArrayExpress
2013-04-13 | E-GEOD-46005 | ArrayExpress
2014-12-12 | E-GEOD-64083 | ArrayExpress
2016-10-12 | E-MTAB-4006 | ArrayExpress
| GSE79533 | GEO
2011-09-08 | E-GEOD-29172 | ArrayExpress
2007-09-01 | E-MEXP-1148 | ArrayExpress
| GSE77270 | GEO
2011-09-08 | E-GEOD-26302 | ArrayExpress