Dataset Information


Transcription profiling by array of FRO thyroid carinoma cell line after the restoration of CBX7 expression

ABSTRACT: We analyzed the expression profile of a thyroid carinoma cell line after the restoration of CBX7 expression.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Alfredo Fusco  

PROVIDER: E-MTAB-2420 | ArrayExpress | 2014-06-01


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CBX7 modulates the expression of genes critical for cancer progression.

Pallante Pierlorenzo P   Sepe Romina R   Federico Antonella A   Forzati Floriana F   Bianco Mimma M   Fusco Alfredo A  

PloS one 20140527 5

We have previously shown that the expression of CBX7 is drastically decreased in several human carcinomas and that its expression progressively decreases with the appearance of a highly malignant phenotype. The aim of our study has been to investigate the mechanism by which the loss of CBX7 expression may contribute to the emergence of a more malignant phenotype.We analyzed the gene expression profile of a thyroid carcinoma cell line after the restoration of CBX7 and, then, analyzed the transcri  ...[more]

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