Transcriptomics

Dataset Information

298

Developmental transcriptome of sexed Anopheles gambiae pupae


ABSTRACT: Overall, the study aims at obtaining a comprehensive picture of the African malaria mosquito, Anopheles gambiae, transcriptome using high-coverage RNA-seq of sexed whole-insect samples collected at different developmental time points. This experiment focuses on transcriptomes of 4 h, 10 h and 20 h old male and female pupae.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Anopheles gambiae  

SUBMITTER: Graham Rose   Jaroslaw Krzywinski  

PROVIDER: E-MTAB-2489 | ArrayExpress | 2015-04-01

SECONDARY ACCESSION(S): ERP005571

REPOSITORIES: ArrayExpress, ENA

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Publications

Dosage Compensation in the African Malaria Mosquito Anopheles gambiae.

Rose Graham G   Krzywinska Elzbieta E   Kim Jan J   Revuelta Loic L   Ferretti Luca L   Krzywinski Jaroslaw J  

Genome biology and evolution 20160118 2


Dosage compensation is the fundamental process by which gene expression from the male monosomic X chromosome and from the diploid set of autosomes is equalized. Various molecular mechanisms have evolved in different organisms to achieve this task. In Drosophila, genes on the male X chromosome are upregulated to the levels of expression from the two X chromosomes in females. To test whether a similar mechanism is operating in immature stages of Anopheles mosquitoes, we analyzed global gene expres  ...[more]

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