Dataset Information



ABSTRACT: Transcription profiling by array of human hepatoma Huh7.5.1-derived cell clones; Huh7.5.1-8 cells highly permissive to HCV and S7-A cells resistant to HCV.

ORGANISM(S): Homo sapiens  

SUBMITTER: Masayoshi Fukasawa  

PROVIDER: E-MTAB-2589 | ArrayExpress | 2014-12-31


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Monoclonal antibodies against extracellular domains of claudin-1 block hepatitis C virus infection in a mouse model.

Fukasawa Masayoshi M   Nagase Shotaro S   Shirasago Yoshitaka Y   Iida Manami M   Yamashita Mayo M   Endo Kohki K   Yagi Kiyohito K   Suzuki Tetsuro T   Wakita Takaji T   Hanada Kentaro K   Kuniyasu Hiroki H   Kondoh Masuo M  

Journal of virology 20150211 9

Hepatitis C virus (HCV) entry into host cells is a complex process requiring multiple host factors, including claudin-1 (CLDN1). Safe and effective therapeutic entry inhibitors need to be developed. We isolated a human hepatic Huh7.5.1-derived cell mutant that is nonpermissive to HCV, and comparative microarray analysis showed that the mutant was CLDN1 defective. Four hybridomas were obtained, which produced monoclonal antibodies (MAbs) that interacted with the parental Huh7.5.1 cell but not wit  ...[more]

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