Dataset Information


MicroRNA profiling by array of human gastric cancer AGS cells after RACK1 silenced or not

ABSTRACT: MicroRNA microarray profiling analysis was performed on human gastric cancer AGS cells after RACK1 silenced or not

ORGANISM(S): Homo sapiens  

SUBMITTER: Chen Ling  

PROVIDER: E-MTAB-2619 | ArrayExpress | 2016-03-01


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Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop.

Chen Ling L   Min Lingqiang L   Wang Xuefei X   Zhao Junjie J   Chen Hua H   Qin Jing J   Chen Weidong W   Shen Zhenbin Z   Tang Zhaoqing Z   Gan Qiangjun Q   Ruan Yuanyuan Y   Sun Yihong Y   Qin Xinyu X   Gu Jianxin J  

Cancer research 20150721 18

Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and invasion and metastasis of gastric cancer represent the major reason for its poor prognosis. In this study, we found that loss of the receptor for activated C-kinase 1 (RACK1) promoted the metastasis of gastric cancer by enhancing the autocrine expression of IL8 in vitro and in vivo. microRNA (miRNA; miR) array identified that RACK1 modulated the expression of a series of miRNAs, including the miR-302 clust  ...[more]

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