Dataset Information


Ionizing radiation exposure of developing mouse brain and cultured neurons

ABSTRACT: The mammalian brain is especially sensitive to ionizing radiation during development, as shown by the increased occurrence of mental retardation and small head size in children who were in utero exposed to ionizing radiation after the atomic bombings of Hiroshima and Nagasaki. These effects of prenatal irradiation can be mimicked by irradiation of mouse embryos during the organogenesis period. In order to better understand the early effects of ionizing radiation on the embryonic brain and immature neurons, we performed a microarray analysis on brains from mice irradiated with different doses at E11 and E14, as well as primary cortical neuron cultures after 14 h in vitro. RNA was extracted at either 2 h (brains) or 6 h (neurons) post-irradiation.

ORGANISM(S): Mus musculus  

SUBMITTER: Mohammed A Benotmane   Roel Quintens  

PROVIDER: E-MTAB-2632 | ArrayExpress | 2015-04-01


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Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development.

Quintens Roel R   Verreet Tine T   Janssen Ann A   Neefs Mieke M   Leysen Liselotte L   Michaux Arlette A   Verslegers Mieke M   Samari Nada N   Pani Giuseppe G   Verheyde Joris J   Baatout Sarah S   Benotmane Mohammed A MA  

Biology open 20150213 3

Ionizing radiation is a potent activator of the tumor suppressor gene p53, which itself regulates the transcription of genes involved in canonical pathways such as the cell cycle, DNA repair and apoptosis as well as other biological processes like metabolism, autophagy, differentiation and development. In this study, we performed a meta-analysis on gene expression data from different in vivo and in vitro experiments to identify a signature of early radiation-responsive genes which were predicted  ...[more]

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