Dataset Information


Developmental transcriptome of sexed Anopheles gambiae larvae and adult mosquitoes group 2

ABSTRACT: Overall, the study aims at obtaining a comprehensive picture of the African malaria mosquito, Anopheles gambiae, transcriptome using high-coverage RNA-seq of sexed whole-insect samples collected at different developmental time points. This experiment focuses on male and female transcriptomes from 4th instar larvae at 12 and 36 hours, and 10 day and 20 day adult mosquitoes. Three biological replicates per sex are included for the 4th instar 12 hour transcriptomes. A single female embryonic 20 hour transcriptome is also included, which is paired with a male transcriptome from the same 20h embryonic timepoint within accession number E-MTAB-2583.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Anopheles gambiae  

SUBMITTER: Graham Rose   Jaroslaw Krzywinski  

PROVIDER: E-MTAB-2665 | ArrayExpress | 2015-04-01



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Dosage Compensation in the African Malaria Mosquito Anopheles gambiae.

Rose Graham G   Krzywinska Elzbieta E   Kim Jan J   Revuelta Loic L   Ferretti Luca L   Krzywinski Jaroslaw J  

Genome biology and evolution 20160118 2

Dosage compensation is the fundamental process by which gene expression from the male monosomic X chromosome and from the diploid set of autosomes is equalized. Various molecular mechanisms have evolved in different organisms to achieve this task. In Drosophila, genes on the male X chromosome are upregulated to the levels of expression from the two X chromosomes in females. To test whether a similar mechanism is operating in immature stages of Anopheles mosquitoes, we analyzed global gene expres  ...[more]

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