Transcriptomics

Dataset Information

299

RNA-seq of vegetatively growing S. pombe cells carrying mutation in RNA-binding protein genes


ABSTRACT: RNA-Seq from vegetatively growing S. pombe cells carrying mutation in RNA-binding protein genes

INSTRUMENT(S): Illumina NextSeq 500

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Juan Mata  

PROVIDER: E-MTAB-2695 | ArrayExpress | 2014-12-01

SECONDARY ACCESSION(S): ERP006204

REPOSITORIES: ArrayExpress, ENA

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Publications

Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan Ayesha A   Cotobal Cristina C   Duncan Caia D S CD   Mata Juan J  

PLoS genetics 20141106 11


mRNA half-lives are transcript-specific and vary over a range of more than 100-fold in eukaryotic cells. mRNA stabilities can be regulated by sequence-specific RNA-binding proteins (RBPs), which bind to regulatory sequence elements and modulate the interaction of the mRNA with the cellular RNA degradation machinery. However, it is unclear if this kind of regulation is sufficient to explain the large range of mRNA stabilities. To address this question, we examined the transcriptome of 74 Schizosa  ...[more]

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