Transcriptomics

Dataset Information

2

Expression profiling of ncRNAs with custom microarray in 3, 10 and 20 month old wild type and 3xTG AD mice


ABSTRACT: In this study, we particularly focused on short ncRNA expression profiling of three, ten and twenty month old triple transgenic mouse model for Alzheimers disease (Oddo et al.; 2003;Neuron). These mice harbor presenilin PS1(M146V), APP(Swedish) and tau(P301L) mutations and develop beta-amyloid plaques and at later stages also a tau pathology. Controls are age matched B6129SF2/J mice.

ORGANISM(S): Mus musculus  

SUBMITTER: Simon Schafferer  

PROVIDER: E-MTAB-2738 | ArrayExpress | 2014-10-31

REPOSITORIES: ArrayExpress

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Publications

Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases.

Gstir Ronald R   Schafferer Simon S   Scheideler Marcel M   Misslinger Matthias M   Griehl Matthias M   Daschil Nina N   Humpel Christian C   Obermair Gerald J GJ   Schmuckermair Claudia C   Striessnig Joerg J   Flucher Bernhard E BE   Hüttenhofer Alexander A  

RNA (New York, N.Y.) 20141024 12


We have generated a novel, neuro-specific ncRNA microarray, covering 1472 ncRNA species, to investigate their expression in different mouse models for central nervous system diseases. Thereby, we analyzed ncRNA expression in two mouse models with impaired calcium channel activity, implicated in Epilepsy or Parkinson's disease, respectively, as well as in a mouse model mimicking pathophysiological aspects of Alzheimer's disease. We identified well over a hundred differentially expressed ncRNAs, e  ...[more]

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