Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: EGAO00000000202EGAS00001000933EGAD00001000986EGAC00001000224
INSTRUMENT(S): Qiagen MinElute, Illumina Hiseq 2000
ORGANISM(S): Homo sapiens
DISEASE(S): Pheochromocytoma
SUBMITTER: Nabila Elarouci
PROVIDER: E-MTAB-2833 | ArrayExpress | 2015-02-02
SECONDARY ACCESSION(S): ERP008960
REPOSITORIES: ArrayExpress, ENA
Action | DRS | |||
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E-MTAB-2833.idf.txt | Idf | |||
E-MTAB-2833.idf.txt_original | Idf | |||
E-MTAB-2833.sdrf.txt | Txt |
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Nature communications 20150127
Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived tumours with a very strong genetic component. Here we report the first integrated genomic examination of a large collection of PCC/PGL. SNP array analysis reveals distinct copy-number patterns associated with genetic background. Whole-exome sequencing shows a low mutation rate of 0.3 mutations per megabase, with few recurrent somatic mutations in genes not previously associated with PCC/PGL. DNA methylation arrays and miRN ...[more]