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In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection

ABSTRACT: S. aureus SA564 and SA564-codY-mutant were grown in bovine aqueous humor, bovine vitreous humor and a chemically defined medium. Samples were extracted in midlog phase and affymetrix microarray processing was performed.

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Ama Sadaka

PROVIDER: E-MTAB-2928 | ArrayExpress | 2015-09-12

REPOSITORIES: ArrayExpress

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	E-MTAB-2928.idf.txt	Idf
	E-MTAB-2928.idf.txt_original	Idf
	E-MTAB-2928.processed.1.zip	Processed
	E-MTAB-2928.raw.1.zip	Raw
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In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection.

Sadaka Ama A Palmer Kelli K Suzuki Takashi T Gilmore Michael S MS

PloS one 20141023 10

<h4>Purpose</h4>To define global transcriptional responses of Staphylococcus aureus and its codY mutant (CodY is a transcription regulator of virulence and metabolic genes in response to branched-chain amino acids) when growing in bovine aqueous (AH) and vitreous humor (VH) in vitro, and to investigate the impact of codY deletion on S. aureus virulence in a novel murine anterior chamber (AC) infection model.<h4>Methods</h4>For the in vitro model, differential transcriptomic gene expression of S. ...[more]

PMID: 25340474

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