Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maddalena Fratelli
PROVIDER: E-MTAB-3097 | ArrayExpress | 2015-04-30
REPOSITORIES: ArrayExpress
Action | DRS | |||
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E-MTAB-3097.idf.txt | Idf | |||
E-MTAB-3097.idf.txt_original | Idf | |||
E-MTAB-3097.raw.1.zip | Raw | |||
E-MTAB-3097.raw.2.zip | Raw | |||
E-MTAB-3097.sdrf.txt | Txt |
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Fisher James Neil JN Fisher James Neil JN Terao Mineko M Fratelli Maddalena M Kurosaki Mami M Paroni Gabriela G Zanetti Adriana A Gianni Maurizio M Bolis Marco M Lupi Monica M Tsykin Anna A Goodall Gregory J GJ Garattini Enrico E
Oncotarget 20150501 15
SKBR3-cells, characterized by ERBB2/RARA co-amplification, represent a subgroup of HER2+ breast-cancers sensitive to all-trans retinoic acid (ATRA) and Lapatinib. In this model, the two agents alone or in combination modulate the expression of 174 microRNAs (miRs). These miRs and predicted target-transcripts are organized in four interconnected modules (Module-1 to -4). Module-1 and Module-3 consist of ATRA/Lapatinib up-regulated and potentially anti-oncogenic miRs, while Module-2 contains ATRA/ ...[more]