Transcriptomics

Dataset Information

43

Transcription profiling by array of compare two pairs of Burkholderia cenocepacia ST32 clinical isolates (from cystic fibrosis patients) subjected to cultivation in two different conditions


ABSTRACT: Burkholderia cenocepacia sequence type 32 (ST32) represents one of the most globally distributed strains from Bukrholderia cepacia complex (Bcc), which infected 30% of Czech cystic fibrosis (CF) patients. The aim of this study was to compare gene expression in two pairs of ST32 clinical isolates that were subjected to cultivation in two different conditions, characteristic for chronic B. cenocepacia infection in CF patients. ST32 strain is known to be a problematic epidemic strain, which caused a serious outbreak at the Prague CF centre.

ORGANISM(S): Burkholderia cenocepacia  

SUBMITTER: Pavel Drevinek   Lucie Kalferstova  

PROVIDER: E-MTAB-3133 | ArrayExpress | 2015-02-27

REPOSITORIES: ArrayExpress

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Publications

Gene expression profiling of Burkholderia cenocepacia at the time of cepacia syndrome: loss of motility as a marker of poor prognosis?

Kalferstova Lucie L   Kolar Michal M   Fila Libor L   Vavrova Jolana J   Drevinek Pavel P  

Journal of clinical microbiology 20150218 5


Cepacia syndrome (CS) is a fatal septic condition that develops in approximately 20% of cystic fibrosis (CF) patients chronically infected with the Burkholderia cepacia complex (Bcc). The most common causative agent is Burkholderia cenocepacia, a clinically dominant Bcc species that contains the globally distributed epidemic strain sequence type 32 (ST32). Using microarrays, we compared the transcriptomes of ST32 isolates from the bloodstream at the time of CS with their sputum counterparts reco  ...[more]

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