Transcriptomics,Multiomics

Dataset Information

5

COPD-MouseExperiment


ABSTRACT: Smoking of combustible cigarettes has a major impact on human health, so the tobacco industry is developing modified risk tobacco products (MRTP) to reduce this health risk. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the potential of such a prototype (pMRTP) to reduce health risk. We investigated physiological endpoints in parallel with transcriptomics, lipidomics, and proteomics profiles in mice exposed to conventional cigarette smoke (3R4F) or a pMRTP aerosol for up to 7 months. We also included a cessation group and a switching-to-pMRTP group (after 2 months of 3R4F exposure) in addition to the control (fresh air-exposed) group, to understand the potential risk reduction of switching to pMRTP compared with continuous 3R4F exposure. The present manuscript describes the study design, setup, and implementation, as well as the generation, processing, and quality control analysis of the toxicology and "omics" datasets that are accessible in public repositories for further studies.

OTHER RELATED OMICS DATASETS IN: PXD001369MTBLS143

INSTRUMENT(S): Affymetrix GeneChip(R) HT Scanner, Affymetrix GeneChip Scanner 3000 7G

ORGANISM(S): Mus musculus  

SUBMITTER: Stephanie Boue   Sam Ansari  

PROVIDER: E-MTAB-3150 | ArrayExpress | 2015-01-30

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MTAB-3150.idf.txt Idf
E-MTAB-3150.processed.1.zip Processed
E-MTAB-3150.raw.1.zip Raw
E-MTAB-3150.raw.10.zip Raw
E-MTAB-3150.raw.11.zip Raw
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Publications


Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of an aerosol derived from a prototype modified risk tobacco product (pMRTP) as compared to conventional cigarettes. We investigated physiological and histological endpoints in parallel with transcriptomics, lipidomics, and proteomics profiles in mice exposed to a reference cigaret  ...[more]

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