Transcriptomics

Dataset Information

31

Microarray Analysis of Differentially Expressed Genes during and after Programmed Death Period of the Sympathetic Neurons


ABSTRACT: To study the changes in the gene expression during neuronal maturation we prepared dissociated cultures of the newborn mouse sympathetic superior cervical ganglia that were grown in vitro for 5 days (young neurons) or 21 days (mature neurons) and compared the pattern of gene expression in the young and mature neurons using Affymetrix Exon array technique. As the cultures contained non-neuronal cells, the young and mature non-neuronal cells without neurons were also included. The assay revealed 1310 significantly up-regulated and 1151 significantly down-regulated genes in the mature neurons compared to young ones.

ORGANISM(S): Mus musculus  

SUBMITTER: Urmas Arumäe   

PROVIDER: E-MTAB-3221 | ArrayExpress| 2015-01-09

REPOSITORIES: ArrayExpress

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Publications

Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons.

Raba Mikk M   Palgi Jaan J   Lehtivaara Maria M   Arumäe Urmas U  

Frontiers in cellular neuroscience 20160316


Postnatal maturation of the neurons whose main phenotype and basic synaptic contacts are already established includes neuronal growth, refinement of synaptic contacts, final steps of differentiation, programmed cell death period (PCD) etc. In the sympathetic neurons, postnatal maturation includes permanent end of the PCD that occurs with the same time schedule in vivo and in vitro suggesting that the process could be genetically determined. Also many other changes in the neuronal maturation coul  ...[more]

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