Dataset Information


MiRNome profiling of glioblastoma tissues and peritumoral regions

ABSTRACT: Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumor. Its prognosis is inexorably unfavorable, as these tumors drive affected patients to death usually within 15 months after diagnosis (short term survivors, ST), with the only exception of a small fraction of patients (long term survivors, LT) surviving longer than 36 months. Even after the frontline therapeutic approach, including surgical resection followed by chemo- and radiotherapy, the cause of death in most cases is tumor recurrence, which occurs in peritumoral tissues in about 95% of patients. Here, we provide a comprehensive molecular analysis of a set of ST and LT samples derived from frankly tumoral areas (C) and from the peritumoral regions (P) of the same patients. By performing microRNA deep sequencing, we collected data showing that P areas differ from healthy white matter, but share with C samples, a number of microRNAs

INSTRUMENT(S): AB 5500xl Genetic Analyzer

ORGANISM(S): Homo sapiens  

SUBMITTER: Alessandro Guffanti   Silvia A Ciafre'  

PROVIDER: E-MTAB-3239 | ArrayExpress | 2017-03-08


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