Transcriptomics

Dataset Information

92

MicroRNA profiling by high-throughput sequencing of HepG2 cells exposed to Benzo[a]pyrene for 6, 12, 18, 24, 36 and 48 hours


ABSTRACT: HepG2 cells (human liver hepatocarcinoma) were exposed for 6 different time points (6,12,18,24,36 and 48h) to Benzo[a]pyrene (BaP) in duplicate.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: florian Caiment   

PROVIDER: E-MTAB-3251 | ArrayExpress| 2015-01-20

SECONDARY ACCESSION(S): ERP009332

REPOSITORIES: ArrayExpress, ENA

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Publications

High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity.

Caiment Florian F   Gaj Stan S   Claessen Sandra S   Kleinjans Jos J  

Nucleic acids research 20150217 5


The chain of events leading from a toxic compound exposure to carcinogenicity is still barely understood. With the emergence of high-throughput sequencing, it is now possible to discover many different biological components simultaneously. Using two different RNA libraries, we sequenced the complete transcriptome of human HepG2 liver cells exposed to benzo[a]pyrene, a potent human carcinogen, across six time points. Data were integrated in order to reveal novel complex chemical-gene interactions  ...[more]

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