Transcriptomics

Dataset Information

55

Methylation profiling by array of 108 clear cell renal cell carcinoma


ABSTRACT: A Cartes d'Identite des Tumeurs (CIT) project from the French Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who might benefit from treatment with targeted tyrosine kinase inhibitors (TKIs) is a challenge. Our aim was to identify molecular markers associated with outcome in m-ccRCC patients treated with sunitinib."

INSTRUMENT(S): Illumina iScan

ORGANISM(S): Homo sapiens  

SUBMITTER: Elarouci Nabila  

PROVIDER: E-MTAB-3274 | ArrayExpress | 2016-02-26

REPOSITORIES: ArrayExpress

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Publications


Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who might benefit from treatment with targeted tyrosine kinase inhibitors (TKI) is a challenge. Our aim was to identify molecular markers associated with outcome in patients with m-ccRCC treated with sunitinib.We performed global transcriptome analyses on 53 primary resected ccRCC tumors from patients who developed metastatic disease and were treated with first-line sunitinib. We also determined chromosome copy-number a  ...[more]

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