Dataset Information


Transcription profiling by array of H1299 cells expressing tetracycline regulated (“tet-off”) delta30 p53 (delta364-393)

ABSTRACT: H1299 cells expressing tetracycline regulated (“tet-off”) delta30 p53 (delta364-393) were previously described (Chen et al., 1996; McKinney et al., 2004).

ORGANISM(S): Homo sapiens  

SUBMITTER: Idit Shiff   Itamar Simon  

PROVIDER: E-MTAB-3362 | ArrayExpress | 2015-03-22


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The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

Laptenko Oleg O   Shiff Idit I   Freed-Pastor Will W   Zupnick Andrew A   Mattia Melissa M   Freulich Ella E   Shamir Inbal I   Kadouri Noam N   Kahan Tamar T   Manfredi James J   Simon Itamar I   Prives Carol C  

Molecular cell 20150301 6

DNA binding by numerous transcription factors including the p53 tumor suppressor protein constitutes a vital early step in transcriptional activation. While the role of the central core DNA binding domain (DBD) of p53 in site-specific DNA binding has been established, the contribution of the sequence-independent C-terminal domain (CTD) is still not well understood. We investigated the DNA-binding properties of a series of p53 CTD variants using a combination of in vitro biochemical analyses and  ...[more]

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