Genomics

Dataset Information

297

The complex pattern of epigenomic variation between natural yeast strains at single-nucleosome resolution


ABSTRACT: We investigated natural inter-individual variation of the epigenome in a quantitative manner. To probe the degree of natural epigenomic diversity in S. cerevisiae, we compared three unrelated wild strains using replicated Mnase-seq and ChIP-seq profiling at mononucleosomal resolution for five histone marks (H3K4me3, H3K9ac, H3K14ac and H4K12ac and H3K4me1).

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Saccharomyces cerevisiae S288C  

SUBMITTER: Filleton Fabien  

PROVIDER: E-MTAB-3390 | ArrayExpress | 2015-07-21

SECONDARY ACCESSION(S): ERP009777

REPOSITORIES: ArrayExpress, ENA

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Publications

The complex pattern of epigenomic variation between natural yeast strains at single-nucleosome resolution.

Filleton Fabien F   Chuffart Florent F   Nagarajan Muniyandi M   Bottin-Duplus Hélène H   Yvert Gaël G  

Epigenetics & chromatin 20150731


BACKGROUND: Epigenomic studies on humans and model species have revealed substantial inter-individual variation in histone modification profiles. However, the pattern of this variation has not been precisely characterized, particularly regarding which genomic features are enriched for variability and whether distinct histone marks co-vary synergistically. Yeast allows us to investigate intra-species variation at high resolution while avoiding other sources of variation, such as cell type or subt  ...[more]

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