Dataset Information


Strain abundance assay of barcoded heterozygous and homozygous yeast single gene deletion strains exposed to 87 psychoactive drugs

ABSTRACT: To profile off-target effects of psychoactive drugs, 87 genome-wide drug fitness assays (of which 5 were performed in duplicate) and 18 genome-wide control experiments were performed in Saccharomyces cerevisiae. Heterozygous and homozygous yeast single gene deletion strains from the BY collection of the Saccharomyces cerevisiae genome deletion consortium were used.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Elke Ericson  

PROVIDER: E-MTAB-34 | ArrayExpress | 2008-07-07


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Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

Ericson Elke E   Gebbia Marinella M   Heisler Lawrence E LE   Wildenhain Jan J   Tyers Mike M   Giaever Guri G   Nislow Corey C  

PLoS genetics 20080808 8

To better understand off-target effects of widely prescribed psychoactive drugs, we performed a comprehensive series of chemogenomic screens using the budding yeast Saccharomyces cerevisiae as a model system. Because the known human targets of these drugs do not exist in yeast, we could employ the yeast gene deletion collections and parallel fitness profiling to explore potential off-target effects in a genome-wide manner. Among 214 tested, documented psychoactive drugs, we identified 81 compoun  ...[more]

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