Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: EGAC00001000328EGAO00000000444EGAD00001001452EGAO00000000377EGAO00000000443EGAS00001001209
ORGANISM(S): Homo sapiens
DISEASE(S): Unknown,High-grade Oligodendroglioma
SUBMITTER: Elarouci Elarouci
PROVIDER: E-MTAB-3457 | ArrayExpress | 2015-07-23
REPOSITORIES: ArrayExpress
Action | DRS | |||
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E-MTAB-3457.idf.txt | Idf | |||
E-MTAB-3457.idf.txt_original | Idf | |||
E-MTAB-3457.raw.1.zip | Raw | |||
E-MTAB-3457.sdrf.txt | Txt |
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Labreche Karim K Simeonova Iva I Kamoun Aurélie A Gleize Vincent V Chubb Daniel D Letouzé Eric E Riazalhosseini Yasser Y Dobbins Sara E SE Elarouci Nabila N Ducray Francois F de Reyniès Aurélien A Zelenika Diana D Wardell Christopher P CP Frampton Mathew M Saulnier Olivier O Pastinen Tomi T Hallout Sabrina S Figarella-Branger Dominique D Dehais Caroline C Idbaih Ahmed A Mokhtari Karima K Delattre Jean-Yves JY Huillard Emmanuelle E Mark Lathrop G G Sanson Marc M Houlston Richard S RS
Nature communications 20150612
Anaplastic oligodendroglioma (AO) are rare primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC and FUBP1. We also identified recurrent mutations in TCF12 and in an additional series of 83 AO. Overall, 7.5% of AO are mutated for TCF12, w ...[more]