Transcriptomics

Dataset Information

7

Differential gene expression between BGC-823/NC and BGC-823/MTA2, SGC-7901/NC and SGC-7901/shMTA2 cells


ABSTRACT: Metastasis associated 1 family, member 2 (MTA2) gene is classified to metastasis associated gene family. We have previously reported that MTA2 gene was overexpressed in gastric cancer tissues, correlating with tumor invasion, lymph node metastasis, and advanced TNM stage. MTA2 knockdown significantly inhibited gastric cancer cell invasion and metastasis. Yet, its molecular mechanisms are still unclear. The aim of this study is to investigate the molecular mechanisms of MTA2 in regulating malignant behaviors of gastric cancer. This experiment captures the expression data between BGC-823/NC and BGC-823/MTA2, SGC-7901/NC and SGC-7901/shMTA2 cells using Whole human genome microarray 4×44K (Design ID: 014850, Agilent technologies).

ORGANISM(S): Homo sapiens  

SUBMITTER: Jun Zhang  

PROVIDER: E-MTAB-3469 | ArrayExpress | 2015-04-08

REPOSITORIES: ArrayExpress

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Publications

MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.

Zhou Chenfei C   Ji Jun J   Cai Qu Q   Shi Min M   Chen Xuehua X   Yu Yingyan Y   Zhu Zhenggang Z   Zhang Jun J  

BMC cancer 20150502


We have preliminarily reported MTA2 expression in gastric cancer and its biological functions by using knockdown cell models, while the molecular mechanisms of MTA2 in regulating malignant behaviors are still unclear.MTA2 overexpression models were established by transfection assay in gastric cancer cells BGC-823 and MKN28. Cell proliferation assay, colony formation in soft agar, wound-healing assay and transwell migration assay were performed with MTA2 overexpression and negative control (NC) c  ...[more]

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