Dataset Information


Thermogenic differentiation of adipocyte progenitors

ABSTRACT: FACS-purified adipocyte progenitors from murine subcutaneous adipose tissue were cultured under conditions promoting general adipogenic differentiation or beige/brite adipocyte differentiation (treatment with cPGI2). Time course expression profiling was performed during differentiation. In addition, some cultures of differentiated adipocytes were stimulated with norepinephrine for 3 hours. In parallel, differentiation and norepinephrine stimulation of progenitors from interscapular brown fat was performed and profiled.

ORGANISM(S): Mus musculus  

SUBMITTER: Alexandros Vegiopoulos  

PROVIDER: E-MTAB-3693 | ArrayExpress | 2015-08-20


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Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning.

Bayindir Irem I   Babaeikelishomi Rohollah R   Kocanova Silvia S   Sousa Isabel Sofia IS   Lerch Sarah S   Hardt Olaf O   Wild Stefan S   Bosio Andreas A   Bystricky Kerstin K   Herzig Stephan S   Vegiopoulos Alexandros A  

Frontiers in endocrinology 20150817

De novo formation of beige/brite adipocytes from progenitor cells contributes to the thermogenic adaptation of adipose tissue and holds great potential for the therapeutic remodeling of fat as a treatment for obesity. Despite the recent identification of several factors regulating browning of white fat, there is a lack of physiological cell models for the mechanistic investigation of progenitor-mediated beige/brite differentiation. We have previously revealed prostacyclin (PGI2) as one of the fe  ...[more]

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