Transcriptomics

Dataset Information

6

MiRNA profiling of longitudinal ovarian cancer biopsies collected before and after platinum-based neo-adjuvant chemotherapy


ABSTRACT: In the last decades platinum-based neo-adjuvant chemotherapy (NACT) has been recognized as a reliable therapeutic strategy in patients with un-resectable advanced epithelial ovarian cancer (EOC). However, the molecular changes induced by NACT at miRNA level, and their prognostic role has not been clarified until now. In order to uncover miRNAs that are altered in EOC tumor which received NACT, we performed whole-miRNA analysis on 82 FIGO Stage IIIC-IV high-grade serous (HGS) tumors, whose samples had been collected at complete primary debulking (PDS) and at interval-debulking surgery (IDS) after fter 4 courses of NACT.

ORGANISM(S): Homo sapiens  

SUBMITTER: Luca Beltrame   Silvia Vicario  

PROVIDER: E-MTAB-3696 | ArrayExpress | 2016-01-20

REPOSITORIES: ArrayExpress

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