Transcriptomics

Dataset Information

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Pancreatic ductal adenocarcinoma primary cultures enriched or not in cancer stem cells


ABSTRACT: RNA sequencing of pancreatic ductal adenocarcinoma (PDAC) primary cultures from five different patient-derived xenograft models grown either in adherent conditions selecting for non-CSCs or in CSC-enriching anchorage-independent sphere conditions. A and B are two biological duplicates, from the same patient-derived xenograft model of PDAC.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Homo sapiens  

SUBMITTER: Matthieu Schoenhals  

PROVIDER: E-MTAB-3808 | ArrayExpress | 2015-11-01

SECONDARY ACCESSION(S): ERP011411

REPOSITORIES: ArrayExpress, ENA

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Publications

In vivo genetic dissection of tumor growth and the Warburg effect.

Wang Cheng-Wei CW   Purkayastha Arunima A   Jones Kevin T KT   Thaker Shivani K SK   Banerjee Utpal U  

eLife 20160901


A well-characterized metabolic landmark for aggressive cancers is the reprogramming from oxidative phosphorylation to aerobic glycolysis, referred to as the Warburg effect. Models mimicking this process are often incomplete due to genetic complexities of tumors and cell lines containing unmapped collaborating mutations. In order to establish a system where individual components of oncogenic signals and metabolic pathways can be readily elucidated, we induced a glycolytic tumor in the Drosophila  ...[more]

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