Transcriptomics

Dataset Information

45

Transcription profiling by array of pig intestinal cells exposed to Zearalenone or E. coli contamination


ABSTRACT: This is a cell culture based study to asses the impact of ZEA (Zearalenone) and E. coli co-contamination on IPEC cells, these is a normal epithelial cell line isolated from a new born piglet. ZEA is a mycotoxin with a negative impact in human health. The microarray is a custom Agilent Technology array slide with the AMAID: 05685.

ORGANISM(S): Sus scrofa  

SUBMITTER: Cornelia Braicu  

PROVIDER: E-MTAB-3885 | ArrayExpress | 2016-11-15

REPOSITORIES: ArrayExpress

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Publications

Zearalenone mycotoxin affects immune mediators, MAPK signalling molecules, nuclear receptors and genome-wide gene expression in pig spleen.

Pistol Gina Cecilia GC   Braicu Cornelia C   Motiu Monica M   Gras Mihail Alexandru MA   Marin Daniela Eliza DE   Stancu Mariana M   Calin Loredana L   Israel-Roming Florentina F   Berindan-Neagoe Ioana I   Taranu Ionelia I  

PloS one 20150526 5


The toxicity of zearalenone (ZEA) was evaluated in swine spleen, a key organ for the innate and adaptative immune response. Weaned pigs were fed for 18 days with a control or a ZEA contaminated diet. The effect of ZEA was assessed on wide genome expression, pro- (TNF-α, IL-8, IL-6, IL-1β, IFN-γ) and anti-inflammatory (IL-10, IL-4) cytokines, other molecules involved in inflammatory processes (MMPs/TIMPs), as well as signaling molecules, (p38/JNK1/JNK2-MAPKs) and nuclear receptors (PPARγ/NFkB/AP-  ...[more]

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