Transcriptomics

Dataset Information

7

Transcription profiling by array of human granulosa cells from individuals with diminished ovarian reserve and egg donors


ABSTRACT: Diminished ovarian reserve (DOR) is a challenging diagonosis of infertility, as there are currently no tests to predict who may become affected with this condition, or at what age. In this study, our aim was to compare the gene expression profile of membrana granulosa cells from young women affected with DOR with those from approximately age-matched egg donors to determine if distinct genetic patterns could be identified to provide insight into the etiology of DOR. Young women with DOR were identified based on FSH level in conjunction with poor follicular development dring an IVF cycle (n=13). Egg donors with normal ovarian reserve comprised the control group (n=13). Granulosa cells were collected following retrieval, RNA was extracted and microarray analysis was conducted to evaluate genetic difference between the groups. Confirmatory studies were undertaken with qRT-PCR. Multiple significant differences in gene expression were observed between the DOR patients and egg donors.

ORGANISM(S): Homo sapiens  

DISEASE(S): Egg Donor (nor),Diminished Ovarian Reserve (dor)

SUBMITTER: Quackenbush John   Shenghua Duan  Racowsky Catherine 

PROVIDER: E-MTAB-391 | ArrayExpress | 2011-09-28

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MTAB-391.README.txt Txt
E-MTAB-391.idf.txt Idf
E-MTAB-391.processed.1.zip Processed
E-MTAB-391.sdrf.txt Txt
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Publications

Ovarian reserve status in young women is associated with altered gene expression in membrana granulosa cells.

Skiadas Christine C CC   Duan Shenghua S   Correll Mick M   Rubio Renee R   Karaca Nilay N   Ginsburg Elizabeth S ES   Quackenbush John J   Racowsky Catherine C  

Molecular human reproduction 20120220 7


Diminished ovarian reserve (DOR) is a challenging diagnosis of infertility, as there are currently no tests to predict who may become affected with this condition, or at what age. We designed the present study to compare the gene expression profile of membrana granulosa cells from young women affected with DOR with those from egg donors of similar age and to determine if distinct genetic patterns could be identified to provide insight into the etiology of DOR. Young women with DOR were identifie  ...[more]

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