Genomics

Dataset Information

298

SPI-1 transcription factor ChIP-Seq


ABSTRACT: To generate and compile data from ChIP-Seq libraries. Looking at genome-wide binding of transcription factors HilD, HilC, RtsA, RtsB, SprB, and InvF under SPI-1 inducing growth conditions in duplicate.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium  

SUBMITTER: Anne M Stringer  

PROVIDER: E-MTAB-3987 | ArrayExpress | 2015-11-05

SECONDARY ACCESSION(S): ERP012904

REPOSITORIES: ArrayExpress, ENA

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Publications

Mapping the Regulatory Network for Salmonella enterica Serovar Typhimurium Invasion.

Smith Carol C   Stringer Anne M AM   Mao Chunhong C   Palumbo Michael J MJ   Wade Joseph T JT  

mBio 20160906 5


Salmonella enterica pathogenicity island 1 (SPI-1) encodes proteins required for invasion of gut epithelial cells. The timing of invasion is tightly controlled by a complex regulatory network. The transcription factor (TF) HilD is the master regulator of this process and senses environmental signals associated with invasion. HilD activates transcription of genes within and outside SPI-1, including six other TFs. Thus, the transcriptional program associated with host cell invasion is controlled b  ...[more]

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