Dataset Information


The impact of Hsp90 upon the Candida albicans transcriptome during heat shock

ABSTRACT: aThese experiments address the effects of depleting Hsp90 upon the transcriptome of the major fungal pathogen, Candida albicans, during the heat shock response. The data show that key virulence factors are regulated in response to heat shock, and that Hsp90 exerts major effects on the heat shock transcriptome.a

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Candida albicans  

SUBMITTER: Eduardo de Paiva Alves   Alistar JP Brown  

PROVIDER: E-MTAB-4075 | ArrayExpress | 2016-05-16



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Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.

Leach Michelle D MD   Farrer Rhys A RA   Tan Kaeling K   Miao Zhengqiang Z   Walker Louise A LA   Cuomo Christina A CA   Wheeler Robert T RT   Brown Alistair J P AJ   Wong Koon Ho KH   Cowen Leah E LE  

Nature communications 20160526

Fever is a universal response to infection, and opportunistic pathogens such as Candida albicans have evolved complex circuitry to sense and respond to heat. Here we harness RNA-seq and ChIP-seq to discover that the heat shock transcription factor, Hsf1, binds distinct motifs in nucleosome-depleted promoter regions to regulate heat shock genes and genes involved in virulence in C. albicans. Consequently, heat shock increases C. albicans host cell adhesion, damage and virulence. Hsf1 activation d  ...[more]

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