Transcriptomics

Dataset Information

1

Transcription profiling by array of NS5 mouse neuronal progenitor cells overexpressing MyT1


ABSTRACT: Here we performed a microarray experiment on samples of adherent cultures of mouse neural stem cells (NS5 cell line) expressing an inducible version of the transcription factor MyT1 (MyT1-V5 TetON) under normal growth conditions and after 4 hours of treatment by doxycyline. This resulted in the generation of a genome-wide mRNA expression pattern and quantification for these cells in the two conditions.

INSTRUMENT(S): AffymetrixMouse Gene 1.0 ST Array

ORGANISM(S): Mus musculus  

SUBMITTER: Diogo S Castro   Francisca F Vasconcelos  

PROVIDER: E-MTAB-4335 | ArrayExpress | 2016-09-09

REPOSITORIES: ArrayExpress

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Publications


The generation of neurons from neural stem cells requires large-scale changes in gene expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. While recent studies have characterized the differentiation genes activated by proneural factors, less is known on the mechanisms that suppress progenitor cell identity. Here, we show that Ascl1 induces the transcription factor MyT1 while promoting neuronal differentiation. We combined functional studies of MyT1  ...[more]

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