Transcriptomics

Dataset Information

5

MicroRNA profiling by array of macrophages infected with Leishmania RNA virus containing Leishmania guyanensis and virus-free parasites


ABSTRACT: Leishmania RNA virus is an endosymbiotic virus of obligate intracellular Leishmania parasites. The presence of Leishmania RNA virus has been associated to metastatic leishmaniasis in hamsters and the failure of the first-line treatment in humans. This experiment aims to find the differences in the microRNA profile of bone-marrow derived macrophages infected with Leishmania RNA virus containing L.guyanensis or virus-free parasites.

INSTRUMENT(S): The Agilent C scanner

ORGANISM(S): Mus musculus  

SUBMITTER: Nicolas Fasel   Remzi Onur Eren  

PROVIDER: E-MTAB-4413 | ArrayExpress | 2016-09-01

REPOSITORIES: ArrayExpress

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Publications

Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.

Eren Remzi Onur RO   Reverte Marta M   Rossi Matteo M   Hartley Mary-Anne MA   Castiglioni Patrik P   Prevel Florence F   Martin Ricardo R   Desponds Chantal C   Lye Lon-Fye LF   Drexler Stefan K SK   Reith Walter W   Beverley Stephen M SM   Ronet Catherine C   Fasel Nicolas N  

Cell host & microbe 20160901 3


Some strains of the protozoan parasite Leishmania guyanensis (L.g) harbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1). LRV1 recognition by TLR-3 increases parasite burden and lesion swelling in vivo. However, the mechanisms by which anti-viral innate immune responses affect parasitic infection are largely unknown. Upon investigating the mammalian host's response to LRV1, we found that miR-155 was singularly and strongly upregulated in macrophages infected with LRV1+ L.g when compar  ...[more]

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