Transcriptomics

Dataset Information

11

Genomic landscape of the individual host response and outcomes in severe sepsis revealed by transcriptomic profiling and quantitative trait mapping (derivation cohort)


ABSTRACT: We assayed leukocyte global gene expression for a prospective discovery cohort of 265 adult patients admitted to UK intensive care units with severe sepsis due to community acquired pneumonia.

ORGANISM(S): Homo sapiens  

SUBMITTER: Emma Davenport  

PROVIDER: E-MTAB-4421 | ArrayExpress | 2016-02-25

REPOSITORIES: ArrayExpress

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Publications

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.

Davenport Emma E EE   Burnham Katie L KL   Radhakrishnan Jayachandran J   Humburg Peter P   Hutton Paula P   Mills Tara C TC   Rautanen Anna A   Gordon Anthony C AC   Garrard Christopher C   Hill Adrian V S AV   Hinds Charles J CJ   Knight Julian C JC  

The Lancet. Respiratory medicine 20160223 4


BACKGROUND:Effective targeted therapy for sepsis requires an understanding of the heterogeneity in the individual host response to infection. We investigated this heterogeneity by defining interindividual variation in the transcriptome of patients with sepsis and related this to outcome and genetic diversity. METHODS:We assayed peripheral blood leucocyte global gene expression for a prospective discovery cohort of 265 adult patients admitted to UK intensive care units with sepsis due to communit  ...[more]

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