Transcriptomics

Dataset Information

4

Microarray analysis of differences in miRNA expression between human mesenchymal stem cells isolated from olfactory mucosa and bone


ABSTRACT: This experiment investigates differences in miRNA expression between different populations of human mesenchymal stem cells (MSCs), which are a potential treatment for multiple sclerosis (MS). Previously it has been reported that MSCs derived from human olfactory mucosa (OM-MSCs) may be a better candidate for the treatment of MS than MSCs derived from bone marrow (BM-MSCs), due to a better ability to promote CNS myelination in vitro. In this study, miRNA profiling of OM-MSCs and BM-MSCs was undertaken to investigate the differences between these two cell types in relation to their prospective therapeutic use.

ORGANISM(S): Homo sapiens  

SUBMITTER: Susan Lindsay   David Mallinson  

PROVIDER: E-MTAB-4594 | ArrayExpress | 2016-06-01

REPOSITORIES: ArrayExpress

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Publications

Comparative miRNA-Based Fingerprinting Reveals Biological Differences in Human Olfactory Mucosa- and Bone-Marrow-Derived Mesenchymal Stromal Cells.

Lindsay Susan Louise SL   Johnstone Steven Andrew SA   McGrath Michael Anthony MA   Mallinson David D   Barnett Susan Carol SC  

Stem cell reports 20160421 5


Previously we reported that nestin-positive human mesenchymal stromal cells (MSCs) derived from the olfactory mucosa (OM) enhanced CNS myelination in vitro to a greater extent than bone-marrow-derived MSCs (BM-MSCs). miRNA-based fingerprinting revealed the two MSCs were 64% homologous, with 26 miRNAs differentially expressed. We focused on miR-146a-5p and miR-140-5p due to their reported role in the regulation of chemokine production and myelination. The lower expression of miR-140-5p in OM-MSCs  ...[more]

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